Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 31077280.
- Also identified by DOI 10.1093/infdis/jiz253.
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Abstract
People with human immunodeficiency virus (HIV) infection (PWH) have an increased risk of cardiovascular disease (CVD), compared with the general population. In a nested case-control study of 55 PWH with first-time myocardial infarction (MI; cases) and 182 PWH with no CVD (controls), we measured soluble markers of interleukin 1 (IL-1) activation at 4 different time points before the case's MI. Cases had higher levels of IL-1 receptor antagonist (IL-1Ra) at all time points leading up to first-time MI, and higher levels of IL-1Ra were associated with an approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation to reduce cardiovascular risk in PWH.
Medical subject headings
- HIV
- HIV Infections
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1beta
- Myocardial Infarction