β-Arrestin2 expressed in mast cells regulates ciprofloxacin-induced pseudoallergy and IgE-mediated anaphylaxis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31077686.
- Also identified by DOI 10.1016/j.jaci.2019.04.024 and PMC identifier 6688937.
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Abstract
The adapter protein β-arrestin2 inhibits Mrgprb2 and FcεRI-mediated mast cell degranulation to attenuate pseudo-allergy and anaphylaxis. Thus, targeting β-arrestin2 in mast cells could provide novel therapeutic options for modulating pseudo-allergy and anaphylaxis.
Medical subject headings
- Anaphylaxis
- Ciprofloxacin
- Drug Hypersensitivity
- Immunoglobulin E
- Mast Cells
- beta-Arrestin 2