Synthetic biology strategies for microbial biosynthesis of plant natural products.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31086174.
- Also identified by DOI 10.1038/s41467-019-09848-w and PMC identifier 6513858.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.
Medical subject headings
- Biological Products
- Metabolic Engineering
- Microorganisms, Genetically-Modified
- Plants