Plasma Biomarkers of Human Immunodeficiency Virus-Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31086991.
- Also identified by DOI 10.1093/infdis/jiz252 and PMC identifier 6688057.
- Licence recorded as CC BY-NC-ND.
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Abstract
We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)-infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive protein, soluble CD163, and soluble scavenger receptor CD14 were significantly higher during ART than in an HIV-uninfected reference group (n = 90), indicating persistent monocyte/macrophage activation, inflammation, and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated soluble CD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. Chemokine (C-C motif) ligand 2, lipopolysaccharide-binding protein, C-reactive protein, and interleukin 6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation.
Medical subject headings
- Anti-HIV Agents
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- C-Reactive Protein
- Carrier Proteins
- Chemokine CCL2
- Chemokine CXCL10
- HIV Infections
- HIV-1
- Interleukin-6
- Lipopolysaccharide Receptors
- Membrane Glycoproteins
- Receptors, Cell Surface