Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 31086993.
- Also identified by DOI 10.1093/cid/ciz361 and PMC identifier 6912151.
- Licence recorded as CC BY-NC-ND.
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Abstract
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.
Medical subject headings
- Agammaglobulinemia
- Poliomyelitis
- Poliovirus