Unsupervised determination of protein crystal structures.
basic_science · Level V
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- Record sourced from PubMed, PMID 31088963.
- Also identified by DOI 10.1073/pnas.1821512116 and PMC identifier 6561213.
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Abstract
We present a method for automatic solution of protein crystal structures. The method proceeds with a single initial model obtained, for instance, by molecular replacement (MR). If a good-quality search model is not available, as often is the case with MR of distant homologs, our method first can automatically screen a large pool of poorly placed models and single out promising candidates for further processing if there are any. We demonstrate its utility by solving a set of synthetic cases in the 2.9- to 3.45-Å resolution.
Medical subject headings
- Crystallography, X-Ray
- Models, Molecular
- Proteins