Attenuation of Unevoked Mechanical and Cold Pain Hypersensitivities Associated With Experimental Neuropathy in Mice by Angiotensin II Type-2 Receptor Antagonism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31094778.
- Also identified by DOI 10.1213/ANE.0000000000003857 and PMC identifier 6652216.
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Abstract
Recent findings from a phase II clinical trial showed analgesic effects of an angiotensin II type-2 receptor (AT2R) antagonist in postherpetic neuralgia patients. This study aimed to investigate whether AT2R antagonism could provide effective analgesia in voluntary measures of unevoked/ongoing pain-like behaviors in mice with experimental neuropathy. Mice were subjected to spared nerve injury to induce neuropathy and tested in 2 operant behavioral tests to measure ongoing mechanical and cold pain hypersensitivities. Systemic administration of an AT2R antagonist provided effective analgesia in these behavioral measures of mechanical and cold pain in spared nerve injury mice, suggesting its effectiveness in neuropathic pain.
Medical subject headings
- Angiotensin II Type 2 Receptor Blockers
- Cold Temperature
- Ganglia, Spinal
- Hyperalgesia
- Neuralgia