"Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31100263.
- Also identified by DOI 10.1016/j.cell.2019.04.034 and PMC identifier 7112349.
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Abstract
A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer "breathing."
Medical subject headings
- Influenza Vaccines
- Influenza, Human