Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31100264.
- Also identified by DOI 10.1016/j.cell.2019.04.033.
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Abstract
Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.
Medical subject headings
- Cues
- Fatty Acids