Retinoblastoma Loss in Cancer: Casting a Wider Net.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31101725.
- Also identified by DOI 10.1158/1078-0432.CCR-19-1292 and PMC identifier 6635068.
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Abstract
Capturing both genomic and nongenomic mechanisms of retinoblastoma gene dysfunction has potential to improve risk stratification and patient selection for biomarker-driven therapy. A 186-gene expression signature is capable of identifying Rb loss across cancer types, providing a new framework for assessing Rb dysfunction based on transcriptome data.<i>See related article by Chen et al., p. 4290</i>.
Medical subject headings
- Retinoblastoma