The role of macrophages in the resolution of inflammation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31107246.
- Also identified by DOI 10.1172/JCI124615 and PMC identifier 6597225.
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Abstract
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.
Medical subject headings
- Homeostasis
- Immunity, Innate
- Macrophages
- Regeneration