The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31107884.
- Also identified by DOI 10.1371/journal.pone.0217002 and PMC identifier 6527237.
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Abstract
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.
Medical subject headings
- Breast Neoplasms
- Calcium-Binding Proteins
- Carcinogenesis
- Membrane Proteins
- Receptors, Notch