Synapsins regulate α-synuclein functions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31110014.
- Also identified by DOI 10.1073/pnas.1903054116 and PMC identifier 6561288.
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Abstract
The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
Medical subject headings
- Synapsins
- Synaptic Vesicles
- alpha-Synuclein