Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.
basic_science · Level V
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- Record sourced from PubMed, PMID 31110017.
- Also identified by DOI 10.1073/pnas.1903049116 and PMC identifier 6561242.
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Abstract
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone-but with no effect on neurotransmission-while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
Medical subject headings
- Synaptic Vesicles
- Vesicle-Associated Membrane Protein 2
- alpha-Synuclein