Association of Severe Influenza Virus Infections With CD226 (DNAM-1) Variants.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 31114873.
- Also identified by DOI 10.1093/infdis/jiz270.
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Abstract
Natural killer (NK)-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether particular CD226 variants were associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076). Also, a higher frequency of rs727088 G and rs763361 T alleles was observed in the ICU group. Thus, CD226 variants may contribute to the severity of influenza virus disease.
Medical subject headings
- Antigens, Differentiation, T-Lymphocyte
- Influenza, Human
- Orthomyxoviridae
- Polymorphism, Single Nucleotide
- Severity of Illness Index