Adjusting cardiopulmonary bypass flow or arterial pressure to maintain renal medullary oxygen.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31122704.
- Also identified by DOI 10.1016/j.kint.2019.02.019.
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Abstract
Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva et al. found that medullary perfusion and tissue oxygen tension (PO<sub>2</sub>) was maintained at low-dose metaraminol, an α<sub>1</sub>-adrenoceptor agonist, because low-dose metaraminol increased perfusion pressure without affecting renal vascular resistance. Lankadeva et al. developed a fiber-optic catheter to measure bladder urine PO<sub>2</sub>. Urine PO<sub>2</sub> tracks medullary PO<sub>2</sub>, and low urine PO<sub>2</sub> predicts acute kidney injury. Adjusting cardiopulmonary bypass to maintain urine PO<sub>2</sub> may help avoid acute kidney injury.
Medical subject headings
- Acute Kidney Injury
- Oxygen