Fracture repair in the elderly: Clinical and experimental considerations.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31130210.
- Also identified by DOI 10.1016/j.injury.2019.05.005 and PMC identifier 7021229.
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Abstract
Fractures in the elderly represent a significant and rising socioeconomic problem. Although aging has been associated with delays in healing, there is little direct clinical data isolating the effects of aging on bone healing from the associated comorbidities that are frequently present in elderly populations. Basic research has demonstrated that all of the components of fracture repair-cells, extracellular matrix, blood supply, and molecules and their receptors-are negatively impacted by the aging process, which likely explains poorer clinical outcomes. Improved understanding of age-related fracture healing should aid in the development of novel treatment strategies, technologies, and therapies to improve bone repair in elderly patients.
Medical subject headings
- Aging
- Bone Regeneration
- Fracture Healing
- Fractures, Bone
- Inflammation
- Osteoporosis