Photocontrollable mononegaviruses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31138700.
- Also identified by DOI 10.1073/pnas.1906531116 and PMC identifier 6575177.
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Abstract
Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.
Medical subject headings
- Measles virus
- Oncolytic Viruses
- Rabies virus