Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 31142578.
- Also identified by DOI 10.1542/peds.2018-3242.
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Abstract
Pulmonary toxicity induced by trimethoprim-sulfamethoxazole (TMP-SMX) has been described, although the disease process is poorly understood. We report 5 previously healthy adolescent patients who developed acute respiratory failure while taking TMP-SMX. Four of the 5 adolescents required extracorporeal membrane oxygenation support, and 2 of the teenagers died. All children required a tracheostomy, and all cases were complicated by pneumothoraces and pneumomediastinum. The majority of children were prescribed TMP-SMX for the treatment of acne vulgaris.
Medical subject headings
- Anti-Bacterial Agents
- Respiratory Insufficiency
- Severity of Illness Index
- Trimethoprim, Sulfamethoxazole Drug Combination