The Integrative Human Microbiome Project.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31142853.
- Also identified by DOI 10.1038/s41586-019-1238-8 and PMC identifier 6784865.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host-microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.
Medical subject headings
- Infant, Premature
- Inflammatory Bowel Diseases
- Microbiota
- National Institutes of Health (U.S.)
- Prediabetic State
- Research