Snatch-and-Grab Inhibitors to Fight the Flu.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31150614.
- Also identified by DOI 10.1016/j.cell.2019.05.033.
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Abstract
Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10-20 nucleotides of 5' capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.
Medical subject headings
- Influenza, Human
- Oxazines
- Pyridines
- Thiepins
- Triazines