AQP4 and the Fate of Gliomas.
editorial · Level V
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- Record sourced from PubMed, PMID 31160309.
- Also identified by DOI 10.1158/0008-5472.CAN-19-1185.
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Abstract
High-grade glioma is the most common primary brain cancer type and is characterized by invasive and fast growth. In a previous issue of <i>Cancer Research</i>, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas. Glioma cell lines expressing the M23-AQP4 isoform, which forms large aggregates of orthogonal arrays of particles, shrink and undergo apoptosis, whereas cell lines expressing the tetramer-forming M1-AQP4 isoform display higher activity of matrix metalloproteinases, making them more invasive. This study provides new insight on the role of AQP4 isoforms in the biology of gliomas.<i>See related article by Simone and colleagues; Cancer Res 79(9):2182-94</i>.
Medical subject headings
- Aquaporin 4
- Glioma