Gallium-68-Labeled Prostate-Specific Membrane Antigen-11 PET/CT of Prostate and Nonprostate Cancers.

Osmany, Saabry; Zaheer, Sumbul; Bartel, Twyla B; Johnston, Mickaila; Peh, Wee Ming; Barmaky, Salwa; Jadvar, Hossein · AJR Am J Roentgenol · 2019

review · Level V

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Abstract

<b>OBJECTIVE.</b> The purpose of this study is to provide a concise summary of the current experience with <sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA)-11 imaging of prostate and nonprostate malignancies and benign conditions. <b>CONCLUSION.</b> PSMA is overexpressed in prostate cancer and in the neovasculature of many other malignancies. The relevance of PSMA as a biologic target, coupled with advances in the design, synthesis, and evaluation of PSMA-based radionuclides for imaging and therapy, is anticipated to play a major role in patient care.

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