Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31167118.
- Also identified by DOI 10.1016/j.cmet.2019.05.013.
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Abstract
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
Medical subject headings
- Citric Acid Cycle
- Pyruvate Carboxylase