Membrane Cholesterol Regulates Macrophage Plasticity in Cancer.
Where this comes from
- Record sourced from PubMed, PMID 31167119.
- Also identified by DOI 10.1016/j.cmet.2019.05.011.
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Abstract
The pro-tumoral diversion of macrophages remains an unresolved paradox of tumor immunology and a conceptual gap in the understanding of tumor biology. Goossens et al. (2019) identify a new level of cross-regulation by which tumors increase the membrane cholesterol efflux of macrophages to enhance their pro-tumoral activation in response to IL-4.
Medical subject headings
- Cholesterol
- Neoplasms