Metabolic Adaptation Sets the Fate of Regulatory Macrophages.
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- Record sourced from PubMed, PMID 31167120.
- Also identified by DOI 10.1016/j.cmet.2019.05.012.
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Abstract
In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintained upon secondary stimulation and alleviate experimental autoimmune encephalomyelitis (EAE) in vivo.
Medical subject headings
- Encephalomyelitis, Autoimmune, Experimental
- Insulin-Like Growth Factor II