Regenerating Hearts by Arresting Development With Hypothyroidism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31170042.
- Also identified by DOI 10.1161/CIRCRESAHA.119.315106 and PMC identifier 6557294.
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Abstract
A recent report by Hirose et al highlights the divergence in cardiac regenerative potential across phylogeny and mouse ontogeny. They provide a correlation between metabolic rate and cardiomyocyte ploidy across species, linking whole-body metabolic control to endothermics and to thyroid function. Specifically, blockade of thyroid hormone signaling may potentiate heart regeneration.
Medical subject headings
- Hypothyroidism