Insights from the Third Dimension: Cardiac Organoids Help Identify Regenerative Pathways.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31173709.
- Also identified by DOI 10.1016/j.stem.2019.05.012.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Mills et al. (2019) use multidimensional functional screening to identify pro-proliferative compounds in cell-cycle-arrested human cardiac organoids. Using this model, the authors identify two hit compounds that restart cardiomyocyte proliferation by synergistically activating the mevalonate pathway and cell-cycle-related pathways.
Medical subject headings
- Mevalonic Acid
- Organoids