Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31173710.
- Also identified by DOI 10.1016/j.stem.2019.05.009.
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Abstract
Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity for the development of novel therapeutics.
Medical subject headings
- Down Syndrome
- Trisomy