CHML promotes liver cancer metastasis by facilitating Rab14 recycle.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31175290.
- Also identified by DOI 10.1038/s41467-019-10364-0 and PMC identifier 6555802.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Neoplasms, Multiple Primary
- rab GTP-Binding Proteins