Microstructure arrays of DNA using topographic control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31175307.
- Also identified by DOI 10.1038/s41467-019-10540-2 and PMC identifier 6555807.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
DNA is a common biomaterial in nature as well as a good building block for producing useful structures, due to its fine feature size and liquid crystalline phase. Here, we demonstrate that a combination of shear-induced flow and microposts can be used to create various kinds of interesting microstructure DNA arrays. Our facile method provides a platform for forming multi-scale hierarchical orientations of soft- and biomaterials, using a process of simple shearing and controlled evaporation on a patterned substrate. This approach enables potential patterning applications using DNA or other anisotropic biomaterials based on their unique structural characteristics.
Medical subject headings
- DNA
- Microtechnology
- Stress, Mechanical