Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days.

Gwee, Amanda; Cranswick, Noel; McMullan, Brendan; Bolisetty, Srinivas; Hunt, Rodney W; Curtis, Nigel; Duffull, Stephen B · JAMA Pediatr · 2019

rct · Level II

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Abstract

This study analyzes data from a randomized clinical trial in infants 90 days and younger to develop a pharmacokinetic model to aid physicians in maintaining minimum inhibitory concentrations of vancomycin in young infants with <i>Staphylococcus aureus</i> infection.