Safety of Endoscopy in Heritable Connective Tissue Disorders.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 31185005.
- Also identified by DOI 10.14309/ajg.0000000000000189.
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Abstract
Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. Clinicians should consider noninvasive screening methods for patients with vascular EDS.
Medical subject headings
- Ehlers-Danlos Syndrome
- Endoscopy, Gastrointestinal
- Intestinal Perforation
- Marfan Syndrome