Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 31190050.
- Also identified by DOI 10.1093/cid/ciz507 and PMC identifier 7319264.
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Abstract
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.
Medical subject headings
- Hematopoietic Stem Cell Transplantation
- Immune Reconstitution Inflammatory Syndrome
- Mycobacterium Infections
- Primary Immunodeficiency Diseases