Integrative modeling of the HIV-1 ribonucleoprotein complex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31194731.
- Also identified by DOI 10.1371/journal.pcbi.1007150 and PMC identifier 6592547.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A coarse-grain computational method integrates biophysical and structural data to generate models of HIV-1 genomic RNA, nucleocapsid and integrase condensed into a mature ribonucleoprotein complex. Several hypotheses for the initial structure of the genomic RNA and oligomeric state of integrase are tested. In these models, integrase interaction captures features of the relative distribution of gRNA in the immature virion and increases the size of the RNP globule, and exclusion of nucleocapsid from regions with RNA secondary structure drives an asymmetric placement of the dimerized 5'UTR at the surface of the RNP globule.
Medical subject headings
- HIV-1
- RNA, Viral
- Ribonucleoproteins
- Viral Proteins