The immunobiology of MIF: function, genetics and prospects for precision medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31197253.
- Also identified by DOI 10.1038/s41584-019-0238-2.
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Abstract
The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by data showing that common functional polymorphisms in MIF are associated with disease susceptibility or clinical severity. MIF can regulate glucocorticoid-mediated immunosuppression and has a prominent function in cell survival signalling. Further specific functions of MIF are now being defined in different autoimmune diseases and MIF-targeted biologic therapeutics are in early-stage clinical trials. The unique structure of MIF is also directing the development of small-molecule MIF antagonists. Together, these efforts could provide a means of selectively intervening in pathogenesis and overcoming MIF-related genetic susceptibility to many rheumatic diseases.
Medical subject headings
- Autoimmune Diseases
- Autoimmunity
- Disease Management
- Genetic Predisposition to Disease
- Intramolecular Oxidoreductases
- Macrophage Migration-Inhibitory Factors
- Polymorphism, Genetic
- Precision Medicine