Mechanistic basis of L-lactate transport in the SLC16 solute carrier family.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31201333.
- Also identified by DOI 10.1038/s41467-019-10566-6 and PMC identifier 6573034.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In human and other mammalian cells, transport of L-lactate across plasma membranes is mainly catalyzed by monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. MCTs play an important role in cancer metabolism and are promising targets for tumor treatment. Here, we report the crystal structures of an SLC16 family homologue with two different bound ligands at 2.54 and 2.69 Å resolution. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structural information together with a detailed structure-based analysis of the transport function provide important insights into the molecular working mechanisms of ligand binding and L-lactate transport.
Medical subject headings
- Bacterial Proteins
- Lactic Acid
- Monocarboxylic Acid Transporters