Platelets attach to lung type 2 innate lymphoid cells (ILC2s) expressing P-selectin glycoprotein ligand 1 and influence ILC2 function.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31201889.
- Also identified by DOI 10.1016/j.jaci.2019.06.001 and PMC identifier 6779509.
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Abstract
Electron microscopy demonstrates that mouse lung ILC2 expressing PSGL-1 have platelets attached to their surface and that platelet depletion reduces lung ILC2 proliferation and Th2 cytokines suggesting ILC2 function is influenced by attachment to platelets.
Medical subject headings
- Blood Platelets
- Immunity, Innate
- Lung
- Lymphocytes
- Membrane Glycoproteins