Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31204280.
- Also identified by DOI 10.1016/j.cmet.2019.05.014.
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Abstract
Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.
Medical subject headings
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hyperlipoproteinemia Type II