The role of PS 18:0/18:1 in membrane function.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31227693.
- Also identified by DOI 10.1038/s41467-019-10711-1 and PMC identifier 6588574.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Various studies have demonstrated that the two leaflets of cellular membranes interact, potentially through so-called interdigitation between the fatty acyl groups. While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between the very-long-chain sphingolipids in the outer leaflet, and phosphatidylserine PS18:0/18:1 in the inner leaflet, and an important role for cholesterol for these interactions. Here we review the evidence that cross-linking of sphingolipids may result in clustering of phosphatidylserine and transfer of signals to the cytosol. Although much remains to be uncovered, the molecular properties and abundance of PS 18:0/18:1 suggest a unique role for this lipid.
Medical subject headings
- Cell Membrane
- Lipid Bilayers
- Phosphatidylserines
- Sphingolipids