A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 31233122.
- Also identified by DOI 10.1093/cid/ciz548.
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Abstract
The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.
Medical subject headings
- Bacteremia
- Bacteriophages
- Mycobacterium tuberculosis
- Tuberculosis
- Tuberculosis, Pulmonary