The Accuracy of Renal Function Measurements in Obstructive Hydronephrosis Using Dynamic Contrast-Enhanced MR Renography.

Abstract

<b>OBJECTIVE.</b> The objective of our study was to assess the accuracy of glomerular filtration rate (GFR) evaluation in patients with obstructive hydronephrosis using dynamic contrast-enhanced MR renography (DCE-MRR). <b>MATERIALS AND METHODS.</b> A group of 28 adult volunteers were enrolled in this study: 13 without hydronephrosis, eight with low-grade hydronephrosis, and seven with high-grade hydronephrosis. The GFR obtained from DCE-MRR (GFR_MRR) and the GFR obtained from renal scintigraphy (GFR_RS) were compared with the reference GFR (GFR_Ref) acquired using the two plasma sample method. The correlation and agreement between GFR_MRR and GFR_Ref, GFR_RS and GFR_Ref, and single-kidney GFR_MRR (skGFR_MRR) and single-kidney GFR_RS (skGFR_RS) were assessed. The interrater reliability of DCE-MRR and the interrater reliability of renal scintigraphy (RS) were measured. <b>RESULTS.</b> Both GFR_MRR and GFR_RS correlated well with GFR_Ref. In patients with hydronephrosis, DCE-MRR and RS overestimated GFR by 12.8 ± 13.9 mL/min (mean ± SD) and 11.5 ± 12.3 mL/min, respectively. The skGFR_RS was higher than skGFR_MRR by 5.7 ± 3.8 mL/min in high-grade hydronephrotic kidneys (<i>p</i> = 0.004). Good interrater reliability was observed for skGFR_MRR (intraclass correlation coefficient [ICC] = 0.82-0.92) and skGFR_RS (ICC = 0.79-0.90) for both nonhydronephrotic kidneys and hydronephrotic kidneys. The overall mean SDs of repeated measurements from three investigators were 4.0 and 3.8 mL/min for skGFR_MRR and skGFR_RS, respectively. <b>CONCLUSION.</b> Both DCE-MRR and RS tend to overestimate GFR in patients with hydronephrosis. RS-derived skGFR is slightly higher than that of DCE-MRR in kidneys with high-grade hydronephrosis. DCE-MRR is comparable to RS and may serve as an alternative noninvasive method for GFR measurement.