Glucose Metabolism Linked to Antiviral Responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31251910.
- Also identified by DOI 10.1016/j.cell.2019.05.057.
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Abstract
Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose metabolism to antiviral responses.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Antiviral Agents