Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31257026.
- Also identified by DOI 10.1016/j.cell.2019.05.047 and PMC identifier 6630709.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-γ-dependent pathway of immune resistance, associated with polarization of a subset of CD4<sup>-</sup> CD8<sup>-</sup> unconventional αβ T cells (UTC<sub>αβ</sub>). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTC<sub>αβ</sub> associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTC<sub>αβ</sub> polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.
Medical subject headings
- Disease Resistance
- Neoplasms
- Neutrophils
- Sarcoma
- T-Lymphocytes