Mismatch Repair-Proficient Colorectal Cancer: Finding the Right TiME to Respond.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31263028.
- Also identified by DOI 10.1158/1078-0432.CCR-19-1447 and PMC identifier 6726523.
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Abstract
New approaches are required for addressing the important and unmet need to expand the benefits of checkpoint blockade to patients with mismatch repair proficient colorectal cancer. Systematic profiling of the tumor immune microenvironment provides insights into potential mechanisms of resistance, predictive biomarkers, and novel combinatorial strategies for overcoming resistance.<i>See related article by Llosa et al., p. 5250</i>.
Medical subject headings
- Colorectal Neoplasms
- DNA Mismatch Repair