Tumor Cholesterol Up, T Cells Down.
Where this comes from
- Record sourced from PubMed, PMID 31269422.
- Also identified by DOI 10.1016/j.cmet.2019.06.007.
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Abstract
Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.
Medical subject headings
- Neoplasms
- Tumor Microenvironment