A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31269423.
- Also identified by DOI 10.1016/j.cmet.2019.06.012 and PMC identifier 6944065.
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Abstract
Ferroptosis is a form of regulated cell death involving lethal peroxidation of phospholipids (Hirschhorn and Stockwell, 2019). Recent results reveal that ferroptosis mediates the tumor suppressive activity of interferon gamma secreted by CD8+ T cells in response to immune checkpoint blockade, suggesting the immune system may function in part through ferroptosis to prevent tumorigenesis (Wang et al., 2019).
Medical subject headings
- CD8-Positive T-Lymphocytes
- Neoplasms