Blood Vessel Proximity Shapes Cancer Cell Metabolism.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31269424.
- Also identified by DOI 10.1016/j.cmet.2019.06.011.
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Abstract
Cancer cells are highly heterogeneous, and their features markedly vary within different areas of the tumor microenvironment. In this issue, Kumar et al. (2019) identified perivascular tumor cells, derived from mouse glioblastoma xenografts, as the fraction that displays the highest mTOR-dependent anabolic metabolism, aggressiveness, and resistance to therapy.
Medical subject headings
- Brain Neoplasms
- Glioblastoma