Putting Stem Cells on a Low-Fat Diet Switches Their Pluripotent State.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31271746.
- Also identified by DOI 10.1016/j.stem.2019.06.002.
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Abstract
Previous work demonstrating the importance of stem cell metabolism in regulating development ignited a debate on how intrinsic versus extrinsic conditions influence metabolic programming of epigenetics. In this issue of Cell Stem Cell, Cornacchia et al. show that exogenous lipids regulate an acetyl-CoA-dependent switch to influence the intrinsic pluripotent state of hPSCs.
Medical subject headings
- Embryonic Stem Cells
- Pluripotent Stem Cells