Filling a gYap in Hepato-Biliary Tissue Integration in Liver Homeostasis and Regeneration.

Itoh, Tohru; Miyajima, Atsushi · Cell Stem Cell · 2019

editorial · Level V

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Abstract

Liver bile ducts serve primarily as drainage for bile and undergo extensive remodeling in response to hepatocyte injuries. In this issue of Cell Stem Cell, Pepe-Mooney et al. (2019) and Planas-Paz et al. (2019) show that Yap signaling can be activated by bile acids and is critical for biliary tissue homeostasis and dynamics.

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